Is Skin penetration a determining factor in skin sensitisation potential and potency? Refuting the notion of a LogKow threshold for Skin Sensitisation
t is widely accepted that substances that cannot penetrate through the skin will not be sensitizers. LogKow and molecular weight (MW) have been used to set thresholds for sensitization potential. Highly hydrophilic substances e.g. LogKow ≤ 1 are expected not to penetrate effectively to induce sensitization. To …